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si bag2  (TargetMol)


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    Structured Review

    TargetMol si bag2
    Inhibition of BAG2 reduced keloid collagen synthesis and deposition. ( A ) The relative gene expression of COL1A1 and TIMP1 in <t>si-BAG2-treated</t> keloid fibroblasts compared to control groups. Gene expression related to collagen synthesis and the inhibition of collagen degradation was significantly reduced following BAG2 inhibition; ( B ) Western blot analysis showing reduced protein expression of BAG2, COL1, COL3, and α-SMA in si-BAG2-treated keloid fibroblasts; ( C ) Masson’s trichrome staining of keloid explants from different groups. Collagen structures in the si-BAG2-treated groups appeared thinner compared to control groups; ( D ) Western blot analysis demonstrates decreasing protein expression of COL1 and COL3 in si-BAG2-treated ex-vivo keloid explants. The reduction in COL1 and COL3 protein expression was statistically significant. Statistical analysis of relative protein expression is provided (n=3). ** P<0.01, **** P<0.0001 .
    Si Bag2, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/si bag2/product/TargetMol
    Average 93 stars, based on 1 article reviews
    si bag2 - by Bioz Stars, 2026-04
    93/100 stars

    Images

    1) Product Images from "Therapeutic Potential of Compounds with High Affinity to BAG2 in Inhibiting Keloid Disease"

    Article Title: Therapeutic Potential of Compounds with High Affinity to BAG2 in Inhibiting Keloid Disease

    Journal: Biologics : Targets & Therapy

    doi: 10.2147/BTT.S533286

    Inhibition of BAG2 reduced keloid collagen synthesis and deposition. ( A ) The relative gene expression of COL1A1 and TIMP1 in si-BAG2-treated keloid fibroblasts compared to control groups. Gene expression related to collagen synthesis and the inhibition of collagen degradation was significantly reduced following BAG2 inhibition; ( B ) Western blot analysis showing reduced protein expression of BAG2, COL1, COL3, and α-SMA in si-BAG2-treated keloid fibroblasts; ( C ) Masson’s trichrome staining of keloid explants from different groups. Collagen structures in the si-BAG2-treated groups appeared thinner compared to control groups; ( D ) Western blot analysis demonstrates decreasing protein expression of COL1 and COL3 in si-BAG2-treated ex-vivo keloid explants. The reduction in COL1 and COL3 protein expression was statistically significant. Statistical analysis of relative protein expression is provided (n=3). ** P<0.01, **** P<0.0001 .
    Figure Legend Snippet: Inhibition of BAG2 reduced keloid collagen synthesis and deposition. ( A ) The relative gene expression of COL1A1 and TIMP1 in si-BAG2-treated keloid fibroblasts compared to control groups. Gene expression related to collagen synthesis and the inhibition of collagen degradation was significantly reduced following BAG2 inhibition; ( B ) Western blot analysis showing reduced protein expression of BAG2, COL1, COL3, and α-SMA in si-BAG2-treated keloid fibroblasts; ( C ) Masson’s trichrome staining of keloid explants from different groups. Collagen structures in the si-BAG2-treated groups appeared thinner compared to control groups; ( D ) Western blot analysis demonstrates decreasing protein expression of COL1 and COL3 in si-BAG2-treated ex-vivo keloid explants. The reduction in COL1 and COL3 protein expression was statistically significant. Statistical analysis of relative protein expression is provided (n=3). ** P<0.01, **** P<0.0001 .

    Techniques Used: Inhibition, Gene Expression, Control, Western Blot, Expressing, Staining, Ex Vivo

    Inhibition of BAG2 reduced KF migration and proliferation via the MEK signaling pathway. ( A ) Representative images and bar graph depict the migration of KFs treated with or without si-BAG2 at 0 and 24 hours after scratching (n=3). Scale bar = 500 μm; ( B ) CCK-8 assays were performed on control and si-BAG2-treated KFs, showing a significant reduction in the proliferation of si-BAG2-treated cells (n=3); ( C ) Relative gene expression of TGF-β in si-BAG2-treated and control KFs, with significantly decreased TGF-β expression observed following si-BAG2 treatment (n=3); ( D ) Western blot analysis revealing decreased p-MEK in si-BAG2-treated cells; ( E ) Representative cell cycle profiles of KFs from various groups, assessed by flow cytometry, accompanied by statistical analysis (n=3). *P<0.05, ** P<0.01, ***P<0.001, **** P<0.0001 . KF, keloid fibroblast.
    Figure Legend Snippet: Inhibition of BAG2 reduced KF migration and proliferation via the MEK signaling pathway. ( A ) Representative images and bar graph depict the migration of KFs treated with or without si-BAG2 at 0 and 24 hours after scratching (n=3). Scale bar = 500 μm; ( B ) CCK-8 assays were performed on control and si-BAG2-treated KFs, showing a significant reduction in the proliferation of si-BAG2-treated cells (n=3); ( C ) Relative gene expression of TGF-β in si-BAG2-treated and control KFs, with significantly decreased TGF-β expression observed following si-BAG2 treatment (n=3); ( D ) Western blot analysis revealing decreased p-MEK in si-BAG2-treated cells; ( E ) Representative cell cycle profiles of KFs from various groups, assessed by flow cytometry, accompanied by statistical analysis (n=3). *P<0.05, ** P<0.01, ***P<0.001, **** P<0.0001 . KF, keloid fibroblast.

    Techniques Used: Inhibition, Migration, CCK-8 Assay, Control, Gene Expression, Expressing, Western Blot, Flow Cytometry



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    si bag2  (TargetMol)
    93
    TargetMol si bag2
    Inhibition of BAG2 reduced keloid collagen synthesis and deposition. ( A ) The relative gene expression of COL1A1 and TIMP1 in <t>si-BAG2-treated</t> keloid fibroblasts compared to control groups. Gene expression related to collagen synthesis and the inhibition of collagen degradation was significantly reduced following BAG2 inhibition; ( B ) Western blot analysis showing reduced protein expression of BAG2, COL1, COL3, and α-SMA in si-BAG2-treated keloid fibroblasts; ( C ) Masson’s trichrome staining of keloid explants from different groups. Collagen structures in the si-BAG2-treated groups appeared thinner compared to control groups; ( D ) Western blot analysis demonstrates decreasing protein expression of COL1 and COL3 in si-BAG2-treated ex-vivo keloid explants. The reduction in COL1 and COL3 protein expression was statistically significant. Statistical analysis of relative protein expression is provided (n=3). ** P<0.01, **** P<0.0001 .
    Si Bag2, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/si bag2/product/TargetMol
    Average 93 stars, based on 1 article reviews
    si bag2 - by Bioz Stars, 2026-04
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    Inhibition of BAG2 reduced keloid collagen synthesis and deposition. ( A ) The relative gene expression of COL1A1 and TIMP1 in si-BAG2-treated keloid fibroblasts compared to control groups. Gene expression related to collagen synthesis and the inhibition of collagen degradation was significantly reduced following BAG2 inhibition; ( B ) Western blot analysis showing reduced protein expression of BAG2, COL1, COL3, and α-SMA in si-BAG2-treated keloid fibroblasts; ( C ) Masson’s trichrome staining of keloid explants from different groups. Collagen structures in the si-BAG2-treated groups appeared thinner compared to control groups; ( D ) Western blot analysis demonstrates decreasing protein expression of COL1 and COL3 in si-BAG2-treated ex-vivo keloid explants. The reduction in COL1 and COL3 protein expression was statistically significant. Statistical analysis of relative protein expression is provided (n=3). ** P<0.01, **** P<0.0001 .

    Journal: Biologics : Targets & Therapy

    Article Title: Therapeutic Potential of Compounds with High Affinity to BAG2 in Inhibiting Keloid Disease

    doi: 10.2147/BTT.S533286

    Figure Lengend Snippet: Inhibition of BAG2 reduced keloid collagen synthesis and deposition. ( A ) The relative gene expression of COL1A1 and TIMP1 in si-BAG2-treated keloid fibroblasts compared to control groups. Gene expression related to collagen synthesis and the inhibition of collagen degradation was significantly reduced following BAG2 inhibition; ( B ) Western blot analysis showing reduced protein expression of BAG2, COL1, COL3, and α-SMA in si-BAG2-treated keloid fibroblasts; ( C ) Masson’s trichrome staining of keloid explants from different groups. Collagen structures in the si-BAG2-treated groups appeared thinner compared to control groups; ( D ) Western blot analysis demonstrates decreasing protein expression of COL1 and COL3 in si-BAG2-treated ex-vivo keloid explants. The reduction in COL1 and COL3 protein expression was statistically significant. Statistical analysis of relative protein expression is provided (n=3). ** P<0.01, **** P<0.0001 .

    Article Snippet: KFs were treated with si-BAG2, C16-PAF (Targetmol, # T21547 , 10 nM), or si-BAG2 alone for 24 and 48 hours, along with the si-NC control.

    Techniques: Inhibition, Gene Expression, Control, Western Blot, Expressing, Staining, Ex Vivo

    Inhibition of BAG2 reduced KF migration and proliferation via the MEK signaling pathway. ( A ) Representative images and bar graph depict the migration of KFs treated with or without si-BAG2 at 0 and 24 hours after scratching (n=3). Scale bar = 500 μm; ( B ) CCK-8 assays were performed on control and si-BAG2-treated KFs, showing a significant reduction in the proliferation of si-BAG2-treated cells (n=3); ( C ) Relative gene expression of TGF-β in si-BAG2-treated and control KFs, with significantly decreased TGF-β expression observed following si-BAG2 treatment (n=3); ( D ) Western blot analysis revealing decreased p-MEK in si-BAG2-treated cells; ( E ) Representative cell cycle profiles of KFs from various groups, assessed by flow cytometry, accompanied by statistical analysis (n=3). *P<0.05, ** P<0.01, ***P<0.001, **** P<0.0001 . KF, keloid fibroblast.

    Journal: Biologics : Targets & Therapy

    Article Title: Therapeutic Potential of Compounds with High Affinity to BAG2 in Inhibiting Keloid Disease

    doi: 10.2147/BTT.S533286

    Figure Lengend Snippet: Inhibition of BAG2 reduced KF migration and proliferation via the MEK signaling pathway. ( A ) Representative images and bar graph depict the migration of KFs treated with or without si-BAG2 at 0 and 24 hours after scratching (n=3). Scale bar = 500 μm; ( B ) CCK-8 assays were performed on control and si-BAG2-treated KFs, showing a significant reduction in the proliferation of si-BAG2-treated cells (n=3); ( C ) Relative gene expression of TGF-β in si-BAG2-treated and control KFs, with significantly decreased TGF-β expression observed following si-BAG2 treatment (n=3); ( D ) Western blot analysis revealing decreased p-MEK in si-BAG2-treated cells; ( E ) Representative cell cycle profiles of KFs from various groups, assessed by flow cytometry, accompanied by statistical analysis (n=3). *P<0.05, ** P<0.01, ***P<0.001, **** P<0.0001 . KF, keloid fibroblast.

    Article Snippet: KFs were treated with si-BAG2, C16-PAF (Targetmol, # T21547 , 10 nM), or si-BAG2 alone for 24 and 48 hours, along with the si-NC control.

    Techniques: Inhibition, Migration, CCK-8 Assay, Control, Gene Expression, Expressing, Western Blot, Flow Cytometry